Associate Director DMPK Oncology R&D
- Recruiter
- AstraZeneca
- Location
-
Essex
East of EnglandUnited Kingdom
- Salary
- Competitive
- Posted
- 02 Oct 2021
- Closes
- 25 Oct 2021
- Job Title
- Associate Director
- Category
- Scientific and Pharmaceutical
- Contract Type
- Permanent
- Hours
- Full Time
*Associate Director DMPK Oncology R&D*
*Permanent Opportunity *
*Location: Cambridge, UK*
Do you have expertise in Oncology, and a passion for ADME and DMPK Science, applied to Cancer biology?
Would you like to apply your expertise to impact the lives of patients in a company that follows the science and turns ideas into life changing medicines? Then AstraZeneca might offer your next career move!
*ABOUT ASTRAZENECA*
AstraZeneca is a global, science–led, patient–focused biopharmaceutical company that focuses on the discovery, development and commercialisation of prescription medicines for some of the world's most serious diseases. But we're more than one of the world's leading pharmaceutical companies.
A place built on courage, curiosity and collaboration – we make bold decisions driven by patient outcomes. Empowered to lead at every level, free to ask questions and take smart risks that write the next chapter for our pipeline and Oncology team.
At AstraZeneca, we're proud to have a unique workplace culture that inspires innovation and collaboration. Here, employees are empowered to express diverse perspectives – and are made to feel valued, energized and rewarded for their ideas and creativity.
*Site Description*
Welcome to Cambridge, one of over 400 sites here at AstraZeneca, providing a collaborative environment where everyone feels comfortable and able to be themselves is at the core of AstraZeneca's priorities, it's important to us that you bring your full self to work every day. To help you maintain your best self, here's a sneak peek into some of the things this site provides for you???
Where life meets Science???*Chesterford Research Park* offers advanced laboratory and office space set within 250 acres of idyllic parkland near Cambridge – modern, dynamic, flexible facilities perfectly appointed for biotechnology, pharmaceutical and R&D companies. You will have access to a stylish, fully air conditioned health and fitness centre, an onsite restaurant, Lunch & Learn development activities, all within a spacious environment while utilising the most advanced technology.
This role will then relocate to the *Cambridge Biomedical Campus*, this site combines world–class biomedical research, patient care and education on a single site location in the heart of Cambridge. This new purpose–built site will bring together the company's research and development activity in a state–of–the–art strategic R&D centre and global corporate headquarters. The building has been designed with the open architecture reflecting AstraZeneca's collaborative approach to research. Open laboratories and transparent glass walls will enable new ways of working across disciplines, whilst a central courtyard will put science on full display.
*BUSINESS AREA*
Be part of fulfilling our ambition to be world leaders in Oncology. We are already the fastest growing team within AstraZeneca and across the industry, and there are countless new indications and targets in our game–changing pipeline. We deliver this value through launch excellence, commercial effectiveness and maximising the lifecycle. By leveraging our commercialised portfolio we are confident we can change the practice of medicine and redefine cancer treatment.
We're brave disruptors – entrepreneurial, courageous and pioneering in our approach. Here you have the opportunity to step up, take personal accountability and lead changes in our ever–evolving environment.
With pace and drive, comes trust that we will get it done. Embrace the freedom to create and expand your horizons. Always backed and supported by pioneering leaders, this is the place to build a world–class career that's meaningful and rewarding.
The vision of AstraZeneca Oncology is to redefine cancer, redefine our solutions to cancer, and restore patients' lives. To achieve this, we have an exciting and diverse portfolio that focuses on four scientific platforms that we believe show the greatest potential for yielding effective medicines for cancer patients. These scientific platforms include; Immuno–Oncology (IO), Tumor Drivers & Resistance (TDR), DNA Damage Response (DDR) and Antibody Drug Conjugates (ADC) and we are developing therapeutic agents across multiple modalities including; small molecules, biologics, Antibody Drug Conjugates (ADCs), nano–medicines and PROTACs.
The Oncology DMPK team is part of Oncology R&D, a core therapeutic area for AstraZeneca.
*What you'll do*
Oncology R&D is a major focus area and growth platform at AstraZeneca. Our vision is to be at the forefront of developing the new generation of cancer therapies. We work together across all boundaries to have a positive impact in the world by solving complicated problems. The Oncology Drug Metabolism and Pharmacokinetics (DMPK) department provides ADME/DMPK, as well as translational PK/PD Modeling & Simulation support to our discovery and development portfolio. We are looking for an individual who has a passion for ADME and DMPK science, applied to Cancer biology
As an Associate Director of DMPK, you will report to the Head of ADME and supervise ADME scientists locally in Cambridge (UK) who provide support for our diverse drug discovery and development portfolio including small molecules, biologics, antibody drugs conjugates (ADCs), nano–medicines and PROTACs. The qualified candidate will also work closely with our DMPK team in Boston (US), maintaining collaboration within the global department. In addition, the selected individual will function as a DMPK Project Representative and be expected to provide direct support for Oncology drug discovery and/or development projects. This senior role is a rare opportunity that requires skills in line management of experimental DMPK science, direct project support and scientific capability development, focused on progressing the AstraZeneca oncology portfolio.
*Accountabilities*
* Supervising and managing a team of ADME scientists by mentoring and challenging them, as well as providing expert advice and context for the interpretation of complex data.
* Representing DMPK as a function in oncology drug discovery and / or development project teams
* Recommending, initiating, leading and championing new innovations that ensure cutting–edge DMPK science is applied to drug project issues.
* Developing and implementing state–of–the–art technologies in the field of in–vitro drug metabolism and transporters including drug–drug interactions in support of discovery projects and suitable for regulatory submissions
* Carrying out collaborative research aligned to DMPK and Oncology objectives and publishing research papers and reviews in internationally recognized journals.
* Fostering collaboration within the global group and brining the enthusiasm to tackle new challenges and learn new skills.
* Managing student and Post Doc programmes.
* Involvement in external collaborative projects with academic or cross–pharma pre–competitive groups.
*Minimum Requirements – Education, Experience and Capabilities*
* PhD or equivalent degree in Pharmaceutical Sciences, Molecular Biology, Chemistry, Biochemistry or Pharmacology with experience in drug discovery and development
* At least 5 years of relevant industry experience in ADME Science and DMPK Project representation within the Pharmaceutical industry
* Strong technical knowledge of DMPK and bioanalytical science with a proven ability to delineate the impact of chemical structure on measured properties.
* Practical experience of DMPK assay delivery including experimentation, assessment of assay quality and troubleshooting of data issues.
* Track record of successful problem solving, high quality science and influencing of stakeholders, particularly in a drug project context.
* Excellent interpersonal skills that lead to successful collaborative working relationships is essential
* Good understanding of the drug discovery process and how DMPK studies contribute to that process
* Desire to carry out scientific development and research work with a view to publishing collaboratively demonstrated by a strong external presentation and publication record. Recognised as an expert in DMPK
* Experience and knowledge of working with multiple modalities including; small molecules, biologics, Antibody Drug Conjugates (ADCs), nano–medicines and PROTACs is a plus.
*Why AstraZeneca?*
At AstraZeneca we're dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There's no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration, and always committed to lifelong learning, growth and development. We're on an exciting journey to pioneer the future of healthcare.
*So, what's next? *
* Are you already imagining yourself joining our team? Good, because we can't wait to hear from you.
*Competitive salary and benefits package on offer.*
*This includes a flexible benefits package, private healthcare, performance bonus, car allowance.*
*Closing date: 1st November 2021 *
*Where can I find out more?*
Our Social Media, Follow AstraZeneca on LinkedIn []()
Follow AstraZeneca on Facebook []()
Follow AstraZeneca on Instagram []()
*Permanent Opportunity *
*Location: Cambridge, UK*
Do you have expertise in Oncology, and a passion for ADME and DMPK Science, applied to Cancer biology?
Would you like to apply your expertise to impact the lives of patients in a company that follows the science and turns ideas into life changing medicines? Then AstraZeneca might offer your next career move!
*ABOUT ASTRAZENECA*
AstraZeneca is a global, science–led, patient–focused biopharmaceutical company that focuses on the discovery, development and commercialisation of prescription medicines for some of the world's most serious diseases. But we're more than one of the world's leading pharmaceutical companies.
A place built on courage, curiosity and collaboration – we make bold decisions driven by patient outcomes. Empowered to lead at every level, free to ask questions and take smart risks that write the next chapter for our pipeline and Oncology team.
At AstraZeneca, we're proud to have a unique workplace culture that inspires innovation and collaboration. Here, employees are empowered to express diverse perspectives – and are made to feel valued, energized and rewarded for their ideas and creativity.
*Site Description*
Welcome to Cambridge, one of over 400 sites here at AstraZeneca, providing a collaborative environment where everyone feels comfortable and able to be themselves is at the core of AstraZeneca's priorities, it's important to us that you bring your full self to work every day. To help you maintain your best self, here's a sneak peek into some of the things this site provides for you???
Where life meets Science???*Chesterford Research Park* offers advanced laboratory and office space set within 250 acres of idyllic parkland near Cambridge – modern, dynamic, flexible facilities perfectly appointed for biotechnology, pharmaceutical and R&D companies. You will have access to a stylish, fully air conditioned health and fitness centre, an onsite restaurant, Lunch & Learn development activities, all within a spacious environment while utilising the most advanced technology.
This role will then relocate to the *Cambridge Biomedical Campus*, this site combines world–class biomedical research, patient care and education on a single site location in the heart of Cambridge. This new purpose–built site will bring together the company's research and development activity in a state–of–the–art strategic R&D centre and global corporate headquarters. The building has been designed with the open architecture reflecting AstraZeneca's collaborative approach to research. Open laboratories and transparent glass walls will enable new ways of working across disciplines, whilst a central courtyard will put science on full display.
*BUSINESS AREA*
Be part of fulfilling our ambition to be world leaders in Oncology. We are already the fastest growing team within AstraZeneca and across the industry, and there are countless new indications and targets in our game–changing pipeline. We deliver this value through launch excellence, commercial effectiveness and maximising the lifecycle. By leveraging our commercialised portfolio we are confident we can change the practice of medicine and redefine cancer treatment.
We're brave disruptors – entrepreneurial, courageous and pioneering in our approach. Here you have the opportunity to step up, take personal accountability and lead changes in our ever–evolving environment.
With pace and drive, comes trust that we will get it done. Embrace the freedom to create and expand your horizons. Always backed and supported by pioneering leaders, this is the place to build a world–class career that's meaningful and rewarding.
The vision of AstraZeneca Oncology is to redefine cancer, redefine our solutions to cancer, and restore patients' lives. To achieve this, we have an exciting and diverse portfolio that focuses on four scientific platforms that we believe show the greatest potential for yielding effective medicines for cancer patients. These scientific platforms include; Immuno–Oncology (IO), Tumor Drivers & Resistance (TDR), DNA Damage Response (DDR) and Antibody Drug Conjugates (ADC) and we are developing therapeutic agents across multiple modalities including; small molecules, biologics, Antibody Drug Conjugates (ADCs), nano–medicines and PROTACs.
The Oncology DMPK team is part of Oncology R&D, a core therapeutic area for AstraZeneca.
*What you'll do*
Oncology R&D is a major focus area and growth platform at AstraZeneca. Our vision is to be at the forefront of developing the new generation of cancer therapies. We work together across all boundaries to have a positive impact in the world by solving complicated problems. The Oncology Drug Metabolism and Pharmacokinetics (DMPK) department provides ADME/DMPK, as well as translational PK/PD Modeling & Simulation support to our discovery and development portfolio. We are looking for an individual who has a passion for ADME and DMPK science, applied to Cancer biology
As an Associate Director of DMPK, you will report to the Head of ADME and supervise ADME scientists locally in Cambridge (UK) who provide support for our diverse drug discovery and development portfolio including small molecules, biologics, antibody drugs conjugates (ADCs), nano–medicines and PROTACs. The qualified candidate will also work closely with our DMPK team in Boston (US), maintaining collaboration within the global department. In addition, the selected individual will function as a DMPK Project Representative and be expected to provide direct support for Oncology drug discovery and/or development projects. This senior role is a rare opportunity that requires skills in line management of experimental DMPK science, direct project support and scientific capability development, focused on progressing the AstraZeneca oncology portfolio.
*Accountabilities*
* Supervising and managing a team of ADME scientists by mentoring and challenging them, as well as providing expert advice and context for the interpretation of complex data.
* Representing DMPK as a function in oncology drug discovery and / or development project teams
* Recommending, initiating, leading and championing new innovations that ensure cutting–edge DMPK science is applied to drug project issues.
* Developing and implementing state–of–the–art technologies in the field of in–vitro drug metabolism and transporters including drug–drug interactions in support of discovery projects and suitable for regulatory submissions
* Carrying out collaborative research aligned to DMPK and Oncology objectives and publishing research papers and reviews in internationally recognized journals.
* Fostering collaboration within the global group and brining the enthusiasm to tackle new challenges and learn new skills.
* Managing student and Post Doc programmes.
* Involvement in external collaborative projects with academic or cross–pharma pre–competitive groups.
*Minimum Requirements – Education, Experience and Capabilities*
* PhD or equivalent degree in Pharmaceutical Sciences, Molecular Biology, Chemistry, Biochemistry or Pharmacology with experience in drug discovery and development
* At least 5 years of relevant industry experience in ADME Science and DMPK Project representation within the Pharmaceutical industry
* Strong technical knowledge of DMPK and bioanalytical science with a proven ability to delineate the impact of chemical structure on measured properties.
* Practical experience of DMPK assay delivery including experimentation, assessment of assay quality and troubleshooting of data issues.
* Track record of successful problem solving, high quality science and influencing of stakeholders, particularly in a drug project context.
* Excellent interpersonal skills that lead to successful collaborative working relationships is essential
* Good understanding of the drug discovery process and how DMPK studies contribute to that process
* Desire to carry out scientific development and research work with a view to publishing collaboratively demonstrated by a strong external presentation and publication record. Recognised as an expert in DMPK
* Experience and knowledge of working with multiple modalities including; small molecules, biologics, Antibody Drug Conjugates (ADCs), nano–medicines and PROTACs is a plus.
*Why AstraZeneca?*
At AstraZeneca we're dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There's no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration, and always committed to lifelong learning, growth and development. We're on an exciting journey to pioneer the future of healthcare.
*So, what's next? *
* Are you already imagining yourself joining our team? Good, because we can't wait to hear from you.
*Competitive salary and benefits package on offer.*
*This includes a flexible benefits package, private healthcare, performance bonus, car allowance.*
*Closing date: 1st November 2021 *
*Where can I find out more?*
Our Social Media, Follow AstraZeneca on LinkedIn []()
Follow AstraZeneca on Facebook []()
Follow AstraZeneca on Instagram []()