Director Oncology Safety Pathology Sciences
- Recruiter
- AstraZeneca
- Location
-
Cambridge
East of EnglandUnited Kingdom
- Salary
- Competitive
- Posted
- 14 Apr 2021
- Closes
- 16 Apr 2021
- Job Title
- Associate Director
- Category
- Scientific and Pharmaceutical
- Contract Type
- Permanent
- Hours
- Full Time
*Director Oncology Safety Pathology Sciences*
*Cambridge UK, Gaithersburg / Boston US*
Competitive salary and benefits
Are you an experienced medical/veterinary pathologist leader with a track record in toxicologic or disease area pathology science? Do you also feel passionate to help deliver life–changing new medicines to oncology patients? We have an exciting opportunity to lead a passionate and dedicated team at the forefront of experimental pathology supporting Oncology R&D.
Join the team that follows the science unlike anywhere else. This is the place for curious minds. Dig deep into the biology of complex disease and uncover breakthroughs.
Oncology Safety is a leading safety organisation that develops and integrates innovative safety science with toxicology excellence to drive the design, selection and successful development of novel oncology therapeutics. Within the Clinical Pharmacology and Safety Sciences (CPSS) function of AstraZeneca R&D and is a diverse international department across Cambridge, UK, Boston and Gaithersburg, US that comprises toxicologists, pathologists, discovery safety specialists, and experimental scientists. We are looking for a Director of Pathology to join our Oncology Safety leadership team to help develop and advance the AstraZeneca portfolio of innovative anti–cancer medicines.
We are seeking an experienced pathologist leader with in depth toxicologic, experimental or medical pathology and a track record of supporting pre–clinical and clinical development of pharmaceutical or biopharmaceuticals . This role requires a leader who is passionate about our early oncology R&D portfolio encompassing classical pharmaceuticals, biologics, antibody drug conjugates, novel tumour targeting technologies and cell therapies as well as mechanisms spanning tumour drivers, DNA damage response, epigenetics and immune–oncology. As such this is a highly visible role that requires vision, strong leadership and dynamic collaboration across R&D functions and a keen focus on talent development.
In addition, we are changing the way pathology and imaging technologies are combined to offer outstanding insight and impact. Our pathologists are empowered by access to artificial intelligence (AI) digital pathology, multiplex assays, sophisticated molecular imaging techniques and a full suite of in vivo imaging technologies. This leadership position therefore offers the opportunity for a forward–thinking pathologist to explore new ways of both the safety and efficacy of drugs within our projects.
*What you'll do*
* Lead the Oncology Safety department pathology team, leading team resource and driving performance to deliver high quality pathology science impacting oncology disease biology and project toxicology pathology.
* Develop team partnerships with discovery safety specialists and toxicologists, bioscientists and translational scientists providing experienced anatomic pathology support to the Early Oncology portfolio.
* Develop and lead oncology safety pathology to support risk assessment of pathology findings in toxicology studies and supplying to mechanistic understanding of target organ toxicities. Ensure high quality study designs, reports from small scale in–house investigational studies to pathology peer review of sponsored GLP studies for regulatory submissions.
* Form a multifaceted partnership with oncology translational science and bioscience functions to deliver tissue–based target biology insight, early biomarker development and application of molecular pathology for safety and efficacy
* Own the development and execution of pathology science strategy exploiting state of the art tissue–based imaging techniques (e.g. MSI, imaging mass cytometry, spatial transcriptomics), data science and AI
* Develop team pathology data science and AI skills and evolve the role of the pathologist to exploit tissue based imaging data, harnessing multi–modal data sources to provide novel and impactful insights to drug research and development
* Make Oncology Safety & Pathology Sciences a great place to work; developing team goals, personal development and encouraging cross–functional collaboration and partnership
*Essential criteria*
* Degree in Veterinary Medicine or Medicine; DVM or MD
* Postgraduate pathology qualification (FRCPath, DACVP, DECVP or DJSTP or similar) and PhD degree
* Genuinely broad cross–species toxicologic pathology expertise with extensive experience of histopathological evaluation and/or peer review of acute, sub–chronic, chronic studies
* Significant experience of leading and providing molecular pathology support to drug discovery and development projects
* Strong familiarity with complementary imaging data (e.g. clinical pathology, IHC, ISH, MSI); ability to integrate pathology findings with a range of traditional and novel endpoints and provide contextualised interpretation for project teams
* Willingness to adopt and champion the use of digital technology for advancing pathology science and delivery of quantitative pathology data
* Highly effective written and oral communication skills with the ability to clearly convey sophisticated pathology data to a wide range of partners
* Specific experience of oncology drug discovery or development, immunopathology, new modalities (including antibody drug conjugates, oncolytic viruses, cell therapies) and animal tumour models (e.g. PDX models, disseminated models) would be advantageous; additional formal training in veterinary clinical pathology also highly desirable.
*Why AstraZeneca*
At AstraZeneca, we 're dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There's no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration. Always committed to lifelong learning, growth and development.
*So, what's next?*
Complete your application before the below closing date.
This role is open from 12 March 21 and welcome with your application no later than 30th April 21
*Where can I find out more?*
Follow AstraZeneca on LinkedIn []()
Follow AstraZeneca on Facebook []()
Follow AstraZeneca on Instagram []()
If you have site, country or departmental social media then feel free to switch any of the above links.
*Cambridge UK, Gaithersburg / Boston US*
Competitive salary and benefits
Are you an experienced medical/veterinary pathologist leader with a track record in toxicologic or disease area pathology science? Do you also feel passionate to help deliver life–changing new medicines to oncology patients? We have an exciting opportunity to lead a passionate and dedicated team at the forefront of experimental pathology supporting Oncology R&D.
Join the team that follows the science unlike anywhere else. This is the place for curious minds. Dig deep into the biology of complex disease and uncover breakthroughs.
Oncology Safety is a leading safety organisation that develops and integrates innovative safety science with toxicology excellence to drive the design, selection and successful development of novel oncology therapeutics. Within the Clinical Pharmacology and Safety Sciences (CPSS) function of AstraZeneca R&D and is a diverse international department across Cambridge, UK, Boston and Gaithersburg, US that comprises toxicologists, pathologists, discovery safety specialists, and experimental scientists. We are looking for a Director of Pathology to join our Oncology Safety leadership team to help develop and advance the AstraZeneca portfolio of innovative anti–cancer medicines.
We are seeking an experienced pathologist leader with in depth toxicologic, experimental or medical pathology and a track record of supporting pre–clinical and clinical development of pharmaceutical or biopharmaceuticals . This role requires a leader who is passionate about our early oncology R&D portfolio encompassing classical pharmaceuticals, biologics, antibody drug conjugates, novel tumour targeting technologies and cell therapies as well as mechanisms spanning tumour drivers, DNA damage response, epigenetics and immune–oncology. As such this is a highly visible role that requires vision, strong leadership and dynamic collaboration across R&D functions and a keen focus on talent development.
In addition, we are changing the way pathology and imaging technologies are combined to offer outstanding insight and impact. Our pathologists are empowered by access to artificial intelligence (AI) digital pathology, multiplex assays, sophisticated molecular imaging techniques and a full suite of in vivo imaging technologies. This leadership position therefore offers the opportunity for a forward–thinking pathologist to explore new ways of both the safety and efficacy of drugs within our projects.
*What you'll do*
* Lead the Oncology Safety department pathology team, leading team resource and driving performance to deliver high quality pathology science impacting oncology disease biology and project toxicology pathology.
* Develop team partnerships with discovery safety specialists and toxicologists, bioscientists and translational scientists providing experienced anatomic pathology support to the Early Oncology portfolio.
* Develop and lead oncology safety pathology to support risk assessment of pathology findings in toxicology studies and supplying to mechanistic understanding of target organ toxicities. Ensure high quality study designs, reports from small scale in–house investigational studies to pathology peer review of sponsored GLP studies for regulatory submissions.
* Form a multifaceted partnership with oncology translational science and bioscience functions to deliver tissue–based target biology insight, early biomarker development and application of molecular pathology for safety and efficacy
* Own the development and execution of pathology science strategy exploiting state of the art tissue–based imaging techniques (e.g. MSI, imaging mass cytometry, spatial transcriptomics), data science and AI
* Develop team pathology data science and AI skills and evolve the role of the pathologist to exploit tissue based imaging data, harnessing multi–modal data sources to provide novel and impactful insights to drug research and development
* Make Oncology Safety & Pathology Sciences a great place to work; developing team goals, personal development and encouraging cross–functional collaboration and partnership
*Essential criteria*
* Degree in Veterinary Medicine or Medicine; DVM or MD
* Postgraduate pathology qualification (FRCPath, DACVP, DECVP or DJSTP or similar) and PhD degree
* Genuinely broad cross–species toxicologic pathology expertise with extensive experience of histopathological evaluation and/or peer review of acute, sub–chronic, chronic studies
* Significant experience of leading and providing molecular pathology support to drug discovery and development projects
* Strong familiarity with complementary imaging data (e.g. clinical pathology, IHC, ISH, MSI); ability to integrate pathology findings with a range of traditional and novel endpoints and provide contextualised interpretation for project teams
* Willingness to adopt and champion the use of digital technology for advancing pathology science and delivery of quantitative pathology data
* Highly effective written and oral communication skills with the ability to clearly convey sophisticated pathology data to a wide range of partners
* Specific experience of oncology drug discovery or development, immunopathology, new modalities (including antibody drug conjugates, oncolytic viruses, cell therapies) and animal tumour models (e.g. PDX models, disseminated models) would be advantageous; additional formal training in veterinary clinical pathology also highly desirable.
*Why AstraZeneca*
At AstraZeneca, we 're dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There's no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration. Always committed to lifelong learning, growth and development.
*So, what's next?*
Complete your application before the below closing date.
This role is open from 12 March 21 and welcome with your application no later than 30th April 21
*Where can I find out more?*
Follow AstraZeneca on LinkedIn []()
Follow AstraZeneca on Facebook []()
Follow AstraZeneca on Instagram []()
If you have site, country or departmental social media then feel free to switch any of the above links.